The body's ability to respond and repair slows down
Things like stress, lack of sleep, poor diet, alcohol, smoking, and pollution speed up that depletion
Besides these catalytic functions, GSTs could also exhibit ligandin functions, binding hydrophobic substrates in a so-called L-site for transport and storage purposes
1994;54:PL638
Several GST isozymes from various classes have been shown to inhibit the function of a kinase involved in the MAPK pathway that regulates cell proliferation and death, preventing the kinase from carrying out its role in facilitating the signaling cascade
Maybe it is a torn rotator cuff that wont heal, a knee that screams when you squat, or a tendonitis flare-up that has turned chronic